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Test Code SIRB Sirolimus

Specimen Type

Whole Blood

Container/Tube

EDTA Lavendar Top

Offsite Collection Instructions

1. Collect sample following standard collection methods
immediately before scheduled dose.
2. Transport room temperature (15 – 25C).

Turnaround Time

N/A

Test Includes

N/A

Preferred Volume

4.0 mL
Microcontainer =0.5 mL

UCMC Collection Instructions

1. Collect sample following standard collection methods
immediately before scheduled dose.
2. Transport room temperature (15 – 25C).

Test Usage

Monitoring whole blood sirolimus concentration during
therapy.

Critical Results

N/A

Test Limitations

N/A

Additional Information

This test was developed and its performance characteristics
determined by The University of Chicago Medical Center Clinical
Chemistry Laboratories in a manner consistent with CLIA requirements. This
test has not been cleared or
approved by the U.S. Food and Drug Administration.

Specimen Minimum Volume

2.0 mL
Microcontainer =0.25 mL

Day(s) Performed

Monday – Friday (7am – 3pm)
Saturday & Sunday (7am – 9am)

STAT DAY(S) AND TIME(S) PERFORMED

N/A

Method Name

Liquid Chromatography/Mass Spectometry
(LC-MS/MS)

Reference Values

3 �?? 20 ng/mL

Therapeutic (reference) ranges for immunosuppressant drugs
have
generally not been well established, as these tend to vary
depending on the type of transplant, patient clinical status
and
post-transplant duration/course, concomitant use of other
pharmacologic agents of the same class, the dosing/collection
intervals and other known factors. This range is based upon
commonly published guidelines, and any results are subject to
physician interpretation and should be used in conjunction with
other diagnostic and clinical information.

Reject Due To

N/A

STAT Turnaround Time

N/A

Included in Additional codes

N/A

Coverage Information

N/A

Stability: Room Temp

7 days

Stability: Refrigerated

7 days

Stability: Frozen

3 months

Specimen and Container/Tube

Whole Blood

Pediatric Volume

2.0 mL
Microcontainer =0.25 mL

Clinical Indications

Monitoring whole blood sirolimus concentration during
therapy.

Transport Instructions

1. Collect sample following standard collection methods
immediately before scheduled dose.
2. Transport?�room temperature (15 �?? 25C).

Test Components

N/A

Specimen Stability

7 days

Rejection Criteria

N/A

Methodology

Liquid Chromatography/Mass Spectometry
(LC-MS/MS)