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The University of Chicago Medicine Laboratories

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Specimen Collection and Handling

Transfusion

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Mayo Clinic Laboratories

Test Code SIRB Sirolimus

Specimen and Container/Tube

Specimen Type: Whole Blood

Preferred Specimen: EDTA Lavender Top

Other Acceptable specimens: None

Volume

Preferred Volume: 4.0 mL

Minimum Volume: 0.2 mL

Specimen Stability

Storage Temperature

Stability

Room temperature

7 days

Refrigerated

7 days

Frozen

3 months

Collection Instructions

Collect specimen per standard laboratory collection procedures immediately before scheduled dose.

 

Specimen Handling and Transport Instructions

UCMC Onsite Instructions: 

Collect specimen per standard collection procedure immediately before scheduled dose and send to laboratory immediately.

 

UCMC Offsite and UC MedLab Outreach Instructions: 

  • Samples should be sent refrigerated. 

Rejection Criteria

  • Common specimen rejected situations include: incorrect specimen type, insufficient volume, missing or incomplete specimen identifiers, incorrect specimen transport, or specimens outside stability limits. 
  • Specimens that are clotted.

Reference Values

Test

Age

Sex

Reference Range

Sirolimus Trough

All

All

4 - 20 ng/mL

Sirolimus Peak

All

All

Not applicable

Therapeutic (reference) ranges for immunosuppressant drugs have generally not been well established, as they tend to vary depending upon type of transplant, patient clinical status and post-transplantation duration/course, concomitant use of other pharmacologic agents of the same class, the dosing/collection intervals and other known factors. The stated range is based upon commonly published guidelines, and any results are subject to physician interpretation and should be used in conjunction with other diagnostic and clinical information. 

Critical Values

Not applicable

Clinical Indications

Monitoring whole blood sirolimus concentration during therapy.

Test Components

Sirolimus 

Methodology

Liquid Chromatography/Mass Spectometry (LC-MS/MS) (Thermo Fisher Scientific)

CPT Codes

80195

LOINC Codes

TBD

Additional Information

  • Results should always be assessed in conjunction with patient's medical history, clinical examination and other findings. 
  • The recommended therapeutic range applies to trough specimens drawn immediately before a dose. Blood drawn at other times will yield higher results.
  • This test was developed and its performance characteristics validated by the UCH Section of Clinical Chemistry.  It has not been approved by the FDA.
  • The UCH Section of Clinical Chemistry is regulated under CLIA and is qualified to perform high complexity testing.  This test should only be used for clinical purposes and should not be regarded as investigational or for research.

Turnaround Time

Turnaround times are relative to the time the specimen is received in the test laboratory. 

 

STAT Turnaround Time: Not available as STAT test

Routine Turnaround Time: 4 hours

Testing Schedule: Monday – Friday (7am – 3pm), Saturday & Sunday (7am – 9am)

Last Review Date

4/10/2025

Synonyms/Keyword Search

Rapamune