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Test Code IAGM IMMUNOGLOBULINS, QUANT

Specimen and Container/Tube

Specimen Type: Plasma

Preferred Specimen: Li-Heparin Mint Green Top

Other Acceptable specimens: Serum/Gold Top

Specimen Handling and Transport Instructions

UCMC Onsite Instructions: 

Collect specimen per standard collection procedure and send to laboratory immediately. 

 

UCMC Offsite and UC MedLab Outreach Instructions: 

  • Samples should be centrifuged within 2 hours of collection.
  • Centrifuge specimens at >2500 x g for 10 minutes at room temperature.
  • Aliquot sample into plastic transport tube containing a minimum of 0.2 mL of specimen.
  • Samples must be sent room temperature at 15-25oC.

Rejection Criteria

  • Common specimen rejected situations include: incorrect specimen type, insufficient volume, missing or incomplete specimen identifiers, incorrect specimen transport, or specimens outside stability limits. 
  • Specimens that are clotted or grossly hemolyzed.
  • Specimens that were transported unspun/whole blood and draw time is greater than 6 hours.

Reference Values

 

Test

Age

Sex

Reference Range

IgG

All

All

 700-1600 mg/dL
IgA All All 70-400 mg/dL
IgM All All 40-230 mg/dL

Note: Reference range based on in-house studies, recommendations from Tietz Textbook of Clinical Chemistry, and Roche product literature.  

Critical Values

Analyte

Unit

Low

High

Age

N/A

N/A

N/A

N/A

N/A

CPT Codes

82784

 

LOINC Codes

2472-9

Volume

Preferred Volume: 0.5 mL

Minimum Volume: 0.2 mL

Specimen Stability

Storage Temperature

Stability

Room temperature

2 months

Refrigerated

4 months

Frozen

6 months

Collection Instructions

Collect specimen per standard laboratory collection procedures. 

 

Test Components

Immunoglobulin A

Immunoglobulin G

Immunoglobulin M

Clinical Indications

The gamma globulin band as seen in conventional serum protein electrophoresis consists of 5 immunoglobulins. In normal serum, about 80% is IgG, 15% is IgA, 5% is IgM, 0.2% is IgD, and a trace is IgE.

 

Elevations of IgG, IgA, and IgM may be due to polyclonal immunoglobulin production.

 

Monoclonal gammopathies of all types may lead to a spike in the gamma globulin zone seen on serum protein electrophoresis. Monoclonal elevations of IgG, IgA, IgD, and IgE characterize multiple myeloma. Monoclonal elevations of IgM occur in macroglobulinemia.

 

Decreased immunoglobulin levels are found in patients with congenital deficiencies.

Methodology

Immunological agglutination (Roche Diagnostics)

Additional Information

  • Increased serum immunoglobulin concentrations occur due to polyclonal or oligoclonal immunoglobulin proliferation in hepatic disease (eg, hepatitis, liver cirrhosis), connective tissue diseases, acute and chronic infections, as well as in the cord blood of neonates with intrauterine and perinatal infections.

     

    Elevations of IgG, IgA, or IgM may occur in monoclonal gammopathies such as multiple myeloma (IgG, IgA), macroglobulinemia (IgM), primary systemic amyloidosis, monoclonal gammopathy of undetermined significance, and related disorders.

     

    Decreased levels are found in patients with primary or secondary immune deficiencies.

Turnaround Time

Turnaround times are relative to the time the specimen is received in the test laboratory. 

 

STAT Turnaround Time: 1 hour

Routine Turnaround Time: 4 hours

Testing Schedule: 24/7

Synonyms/Keyword Search

IgA (Immunoglobulins)

IgA, IgG, IgM (Immunoglobulins A, G, M)

IgG (Immunoglobulins)

IgM (Immunoglobulins)

Immune Competence

Immunoglobulin Panel, Serum

Immunoglobulins, Quantitative

Macroglobulins

Quant Ig, Serum

Immunoglobulin G (IgG)

Immunoglobulin M (IgM)

Immunoglobulin A (IgA)

Gamma-Globulins, Quantitative

Last Review Date

07/02/2024