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Test Code HSTROT High Sensitive Troponin T (Gen 5)

Specimen and Container/Tube

Specimen Type: Plasma

Preferred Specimen: Li-Heparin Mint Green Top

Other Acceptable specimens: None

Specimen Handling and Transport Instructions

UCMC Onsite Instructions: 

Collect specimen per standard collection procedure and send to laboratory immediately.  Samples must be received within 2 hours of collection.

 

UCMC Offsite and UC MedLab Outreach Instructions: 

  • Samples must be centrifuged within 2 hours of collection.
  • Centrifuge specimens at >2500 x g for 10 minutes at room temperature.
  • Aliquot sample into plastic transport tube containing a minimum of 0.2 mL of specimen.
  • Samples must be sent refrigerated (2 – 8˚C). If delay is greater then 24 hours, samples must be sent frozen on ice.

Rejection Criteria

  • Common specimen rejected situations include: incorrect specimen type, insufficient volume, missing or incomplete specimen identifiers, incorrect specimen transport, or specimens outside stability limits. 
  • Specimens that are clotted or grossly hemolyzed.
  • Specimens that were transported unspun/whole blood and draw time is greater than 2 hours.

Reference Values

 

Test

Age

Sex

Reference Range

High Sensitive Troponin T

All

Male

<22 ng/L

High Sensitive Troponin T

All

Female

<14 ng/L

Note: Reference range based on in-house studies and Roche Diagnositcs package insert, and published literature.

Critical Values

Analyte

Unit

Low

High

Age

High Sensitive Troponin T 

N/A

N/A

N/A

N/A

CPT Codes

84484

LOINC Codes

89579-7

Volume

Preferred Volume: 0.5 mL

Minimum Volume: 0.2 mL

Specimen Stability

Storage Temperature

Stability

Room temperature

 N/A

Refrigerated

 24 Hours

Frozen

 12 Months

Collection Instructions

Collect specimen per standard laboratory collection procedures. 

 

Test Components

High Sensitive Troponin T

Clinical Indications

Due to its high cardio-specificity, cardiac troponin T (cTnT) is a highly sensitive marker for cardiac damage. The Elecsys Cardiac Troponin T assay can be used as an aid in the differential diagnosis of acute coronary syndrome (e.g. acute myocardial infarction). Diagnosis of AMI requires acute changes in cTnT with at least one serial sample to be above the 99th percentile of the upper reference limit, with clinical evidence of myocardial ischemia. The test is further indicated for the risk stratification of patients presenting with acute coronary syndrome and for cardiac risk in patients with chronic renal failure. The test may also be useful for the selection of more intensive therapy and intervention in patients with elevated levels of cardiac troponin T.

Methodology

Electrochemiluminescence Immunoassay (ECLIA) (Roche Diagnostics)

Additional Information

  • Results should always be assessed in conjunction with patient's medical history, clinical examination and other findings.
  • Falsely depressed results are obtained when using samples with hemoglobin concentrations > 0.1 g/dL.
  • Samples with visible signs of hemolysis (H-Index >100) will be rejected.
  • The possibility exists for interferences by heterophile antibodies in patients exposed chronically to animals or have received immunotherapy/diagnostic procedures using immunoglobulin. The interference effect could result in a false positive cTnT reading.
  • In rare cases, extremely high titers of antibodies to analyte-specific reagents may cause interferences.
  • Elevated cTnT concentrations can also occur in other clinical conditions such as myocarditis, heart contusions, pulmonary embolism and drug-induced cardiotoxicity.

Turnaround Time

Turnaround times are relative to the time the specimen is received in the test laboratory. 

 

STAT Turnaround Time: 1 hour

Routine Turnaround Time: 4 hours

Testing Schedule: 24/7

Synonyms/Keyword Search

N/A

Last Review Date

2/24/2023