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HelpTest Code HAABT Hepatitis A Virus Antibodies Total
Infectious
Specimen and Container/Tube
Specimen Type: Serum
Preferred Specimen: Red Top
Specimen Handling and Transport Instructions
UCMC Onsite Instructions:
Collect specimen per standard collection procedure and send to laboratory immediately.
UCMC Offsite and UC MedLab Outreach Instructions:
- Samples should be centrifuged within 2 hours of collection.
- Centrifuge specimens at >2500 x g for 10 minutes at room temperature.
- Aliquot sample into plastic transport tube containing a minimum of 0.2 mL of specimen.
- Samples must be sent room temperature at 15-25oC.
Rejection Criteria
- Common specimen rejected situations include: incorrect specimen type, insufficient volume, missing or incomplete specimen identifiers, incorrect specimen transport, or specimens outside stability limits.
- Specimens that are clotted or grossly hemolyzed.
- Specimens that were transported unspun/whole blood and draw time is greater than 6 hours
Reference Values
This is a qualitative test. The absence of antibody to hepatitis A virus is considered normal. However, a negative test result does not exclude the possibility of exposure to HAV and/or early acute hepatitis A viral infection.
|
Test |
Age |
Sex |
Reference Range |
Interpretation |
|
HAABT |
All |
All |
≤1.0 COI |
Reactive |
|
HAABT |
All |
All |
>1.0 COI |
Non-Reactive |
Critical Values
|
Analyte |
Unit |
Low |
High |
Age |
|
N/A |
N/A |
N/A |
N/A |
N/A |
CPT Codes
86708
LOINC Codes
13951-9
Volume
Preferred Volume: 0.5 mL
Minimum Volume: 0.2 mL
Specimen Stability
|
Storage Temperature |
Stability |
|
Room Temperature |
6 days |
|
Refrigerated |
14 days |
|
Frozen |
3 months |
Note: May be frozen up to 5 times.
Collection Instructions
Collect specimen per standard laboratory collection procedures.
Test Components
Hepatitis A Virus Total Antibodies
Clinical Indications
Hepatitis A virus (HAV) is endemic throughout the world, occurring most commonly in areas of poor hygiene and low socioeconomic conditions. The virus is transmitted primarily by the fecal-oral route and spread by close person-to-person contact and by food and waterborne epidemics. Outbreaks frequently occur in overcrowded situations and high-density institutions and centers, such as prisons and healthcare or daycare centers. Viral spread by parenteral routes (eg, exposure to blood) is possible, but rare, because infected individuals are viremic for a short period of time (usually <3 weeks). There is little or no evidence of transplacental transmission from mother to fetus or transmission to newborn during delivery.
Methodology
Electrochemiluminescence immunoassay (ECLIA) (Roche Diagnostics)
Additional Information
This assay detects the presence of hepatitis A virus (HAV)-specific IgM antibody in serum.
Negative results indicate either inadequate or delayed anti-HAV IgM response after known exposure to HAV or absence of acute or recent hepatitis A.
Equivocal results may be seen in early acute hepatitis A associated with rising anti-HAV IgM levels or recent hepatitis A infection associated with declining anti-HAV IgM levels. Retesting for both anti-HAV IgM (HAIGM / Hepatitis A Virus IgM Antibody, Serum) and anti-HAV Total (HAVTA / Hepatitis A Virus Total Antibodies, Serum) in 2 to 4 weeks is recommended to determine the definitive HAV infection status.
Positive results indicate acute or recent (<6 months) hepatitis A infection. As required by laws in almost all states, positive anti-HAV IgM test results must be urgently reported to state health departments for epidemiologic investigations of possible outbreak transmission.
Turnaround Time
Turnaround times are relative to the time the specimen is received in the test laboratory.
STAT Turnaround Time: Not available as STAT test
Routine Turnaround Time: up to 4 hours
Testing Schedule: 24/7
Synonyms/Keyword Search
HAABt
Anti-HAV Total
Hepatitis A Virus IgM & IgG Antibodies
AHAVT
Last Review Date
06/14/2024