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Test Code PECRA Preeclampsia sFlt-1/PlGF RatioPreeclampsia sFlt-1/PlGF Ratio

Important Note

This test is FDA approved for inpatient testing ONLY for pregnant women, with singleton pregnancies (gestational age 23+0 to 34+6/7 weeks) hospitalized for hypertensive disorders of pregnancy (preeclampsia, chronic hypertension with or without superimposed preeclampsia, or gestational hypertension), within 2 weeks of presentation.

Specimen and Container/Tube

Specimen Type: Serum

Preferred Specimen: Red Top

Other Acceptable specimens: None

Specimen Stability

Storage Temperature

Stability

Room temperature

6 days

Refrigerated

15 days

Frozen

6 months 

Freeze only once

Collection Instructions

Collect specimen per standard collection procedures. 

 

Specimen Handling and Transport Instructions

UCMC Onsite Instructions: 

Send specimen to laboratory at Room Temperature.

 

UCMC Offsite and UC MedLab Outreach Instructions: 

Send specimen to laboratory at Room Temperature.

Rejection Criteria

  • Common specimen rejected situations include: incorrect specimen type, insufficient volume, missing or incomplete specimen identifiers, incorrect specimen transport, or specimens outside stability limits. 

Reference Values

 

Test

Age

Sex

Reference Range

sFlt/PlGF Ratio

All

All

<39

 

Turnaround Time

Turnaround times are relative to the time the specimen is received in the test laboratory. 

 

STAT Turnaround Time: 1 hour

Routine Turnaround Time: 4 hours

Testing Schedule: 24/7

Clinical Indications

The sFlt-1/PlGF ratio is FDA approved for clinical use as a prognostic aid for risk assessment in pregnant women with a singleton pregnancy (23+0 to 34+6/7 weeks' gestation) who are hospitalized for hyertensive disorders of pregnancy to assess the risk of developing preeclampsia with severe features within 2 weeks of testing.  The sFlt-1/PlGF ratio should be used in conjuction with clnical assessment and routine laboratory testing.

Methodology

The electrochemiluminescence immunoassay “ECLIA” is intended for use on cobas e immunoassay analyzers.

CPT Codes

83520 (x2)

LOINC Codes

TBD

Synonyms/Keyword Search

PECRA, Preeclampsia, sflt-1, PlGF, sflt-1/plgf ratio

Last Review Date

2/20/2026

Critical Values

Not applicable

Volume

Preferred Volume: 1.0 mL

Minimum Volume: 0.5 mL

Test Components

sFLT-1, PlGF, sFLT-1/PlGF Ratio

Additional Information

This assay should not be used in pregnant women who have received heparin within 36 hours of this testing due to interference at heparin concentrations >500 U/L.