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Test Code TRYP Alpha-1-Antitrypsin

Specimen and Container/Tube

Specimen Type: Plasma

Preferred Specimen: Li-Heparin Mint Green Top

Other Acceptable specimens: Serum/Gold Top, Serum/Red Top, Plasma/Lavendar K2 Top

Specimen Handling and Transport Instructions

UCMC Onsite Instructions: 

Collect specimen per standard collection procedure and send to laboratory immediately.

 

UCMC Offsite and UC MedLab Outreach Instructions: 

  • Samples should be centrifuged within 2 hours of collection.
  • Centrifuge specimens at >2500 x g for 10 minutes at room temperature.
  • Aliquot sample into plastic transport tube containing a minimum of 0.2 mL of specimen.
  • Samples must be sent room temperature at 15-25oC.

Rejection Criteria

  • Common specimen rejected situations include: incorrect specimen type, insufficient volume, missing or incomplete specimen identifiers, incorrect specimen transport, or specimens outside stability limits. 
  • Specimens that are clotted or grossly hemolyzed.
  • Specimens that were transported unspun/whole blood and draw time is greater than 6 hours.

Reference Values

 

Test

Age

Sex

Reference Range

Alpha-1-Antitrypsin

All

All

92-200 mg/dL

Critical Values

Analyte

Unit

Low

High

Age

N/A

N/A

N/A

N/A

N/A

CPT Codes

82103

LOINC Codes

1825-9

Volume

Preferred Volume: 0.5 mL

Minimum Volume: 0.2 mL

Specimen Stability

Storage Temperature

Stability

Room temperature

7 days

Refrigerated

3 months

Frozen

3 months

Collection Instructions

Collect specimen per standard laboratory collection procedures.

 

Test Components

Alpha-1-Antitrypsin

Clinical Indications

Alpha-1-Antitrypsin (A1AT) is an important, positive acute phase reactant found in elevated concentrations in inflammatory processes (e.g.infectious and rheumatoid diseases), tissue necrosis, malignancy and traumas.Useful in diagnosis of alpha-1-antitrypsin deficiency. May be useful in the work-up of individuals with suspected disorders such as familial chronic obstructive lung disease.

Methodology

Immunoturbidimetric Assay (Roche Diagnostics)

Additional Information

  • Results should always be assessed in conjunction with patient's medical history, clinical examination and other findings. 
  • Elevated estrogen levels (oral contraceptives; third trimester of pregnancy) give rise to increased values. CRP and haptoglobin should therefore also be determined.

Turnaround Time

Turnaround times are relative to the time the specimen is received in the test laboratory. 

 

STAT Turnaround Time: 1 hour

Routine Turnaround Time: 4 hours

Testing Schedule: 24/7

Synonyms/Keyword Search

Anti-Alpha-1-Trypsin, Prolastin, A1A, AAT, A1AT

Last Review Date

8/19/2024