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Test Code TRYP Alpha-1-Antitrypsin

Specimen and Container/Tube

Specimen Type: Plasma

Preferred Specimen: Li-Heparin Mint Green Top

Other Acceptable specimens: Serum/Gold Top, Serum/Red Top

Specimen Stability

Storage Temperature

Stability

Room temperature

7 days

Refrigerated

3 months

Frozen

3 months

Collection Instructions

Collect specimen per standard laboratory collection procedures.

 

Specimen Handling and Transport Instructions

UCMC Onsite Instructions: 

Collect specimen per standard collection procedure and send to laboratory immediately.

 

UCMC Offsite and UC MedLab Outreach Instructions: 

  • Samples should be centrifuged within 2 hours of collection.
  • Centrifuge specimens at >2500 x g for 10 minutes at room temperature.
  • Aliquot sample into plastic transport tube containing a minimum of 0.2 mL of specimen.
  • Samples must be sent room temperature at 15-25oC.

Rejection Criteria

  • Common specimen rejected situations include: incorrect specimen type, insufficient volume, missing or incomplete specimen identifiers, incorrect specimen transport, or specimens outside stability limits. 
  • Specimens that are clotted or grossly hemolyzed.
  • Specimens that were transported unspun/whole blood and draw time is greater than 6 hours.

Reference Values

 

Test

Age

Sex

Reference Range

Alpha-1-Antitrypsin

All

All

92-200 mg/dL

Critical Values

Not applicable 

Turnaround Time

Turnaround times are relative to the time the specimen is received in the test laboratory. 

 

STAT Turnaround Time: 1 hour

Routine Turnaround Time: 4 hours

Testing Schedule: 24/7

Clinical Indications

Alpha-1-Antitrypsin (A1AT) is an important, positive acute phase reactant found in elevated concentrations in inflammatory processes (e.g.infectious and rheumatoid diseases), tissue necrosis, malignancy and traumas.Useful in diagnosis of alpha-1-antitrypsin deficiency. May be useful in the work-up of individuals with suspected disorders such as familial chronic obstructive lung disease.

Test Components

Alpha-1-Antitrypsin

CPT Codes

82103

LOINC Codes

1825-9

Methodology

Immunoturbidimetric Assay (Roche Diagnostics)

Synonyms/Keyword Search

Anti-Alpha-1-Trypsin, Prolastin, A1A, AAT, A1AT

Additional Information

  • Results should always be assessed in conjunction with patient's medical history, clinical examination and other findings. 
  • Elevated estrogen levels (oral contraceptives; third trimester of pregnancy) give rise to increased values. CRP and haptoglobin should therefore also be determined.

Last Review Date

8/19/2024

Volume

Preferred Volume: 0.5 mL

Minimum Volume: 0.2 mL