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Test Code RPRCR Urine Protein and Creatinine with Ratio, Random 

Specimen and Container/Tube

Specimen Type: Urine, Random Collection

Preferred Specimen: Sterile Plastic Container

Other Acceptable specimens: Sterile Clean Glass Container

Specimen Stability

Storage Temperature

Stability

Room temperature

 8 hours

Refrigerated

2 days

Frozen

6 months

not preferred

Collection Instructions

  • Collect specimen per standard laboratory collection procedures. 
  • No preservatives or additives.

Specimen Handling and Transport Instructions

UCMC Onsite Instructions: 

  • Collect specimen per standard collection procedure and send to laboratory immediately. 
  • No preservatives or additives.

 

UCMC Offsite and UC MedLab Outreach Instructions: 

  • Samples should be centrifuged within 2 hours of collection
  • No preservatives or additives
  • Centrifuge specimens at >2500 x g for 10 minutes at room temperature.
  • Aliquot urine into plastic tube containing a minimum of 0.2 mL of specimen.
  • Urine samples must then be sent refrigerated at 2-8oC.

Rejection Criteria

  • Common specimen rejected situations include: incorrect specimen type, insufficient volume, missing or incomplete specimen identifiers, incorrect specimen transport, or specimens outside stability limits. 
  • Specimens that are collected with preservatives or additives.

Reference Values

Test

Age

Sex

Reference Range

Urine Protein

All

All

NA

Urine Creatinine

All

All

NA

Urine Protein/Creatinine Ratio

All

All
  •  Normal to Mildly Increased: <150 mg/g
  • Moderately Increased: 150 - 500 mg/g
  • Severly Increased: >500 mg/g" 

The following reference range is according to KDIGO Clinical Practice Guideline for evaluation andmanagement of CKD (Kidney Inter., Suppl. 2013; 3: 1-150)

Critical Values

Not applicable 

Turnaround Time

Turnaround times are relative to the time the specimen is received in the test laboratory. 

STAT Turnaround Time: 1 hour

Routine Turnaround Time: 4 hours

Testing Schedule: 24/7

Clinical Indications

For the determination of the urine protein to urine creatinine ratio.

Test Components

Urine protein random, Urine creatinine random, urine protein/creatinine ratio 

CPT Codes

85270, 84156

LOINC Codes

2161-8

Methodology

Urine protein: Turbidimetric (Benzethonium Chloride) Method (Roche Diagnostics)

Urine creatinine: Kinetic Colorimetric assay enzymatic method (Roche Diagnostics)

Synonyms/Keyword Search

Not applicable 

Additional Information

  • Results should always be assessed in conjunction with patient's medical history, clinical examination and other findings. 

Last Review Date

4/4/2025

Volume

Preferred Volume: 0.5 mL

Minimum Volume: 0.2 mL