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Mayo Clinic Laboratories

Test Code NPM NPM1 Mutation Analysis (Blood)

Important Note

Starting on 05/22/2017, the University of Chicago Molecular Pathology Laboratory launched a new NGS assay for the detection of mutations in Exon 11 of NPM1 gene. This test replaces the previous fragment analysis based qualitative assay and has a much improved analytical sensitivity (0.2% vs 5%).  

 

Additional Codes

n/a

Specimen and Container/Tube

Blood

Rejection Criteria

Inappropriate anticoagulant and >72 hours

Clinical Indications

May be used to monitor low level residual disease in acute
myeloid leukemia (AML) patients.

Test Components

Detects NPM1 insertion mutations in Exon 11

Methodology

Next Generation Sequencing

Test Includes

Detects NPM1 insertion mutations in Exon 11

Specimen Type

Blood

Preferred Volume

3 mL

Turnaround Time

Not Available

Test Usage

May be used to monitor low level residual disease in acute
myeloid leukemia (AML) patients.

Synonyms

NPM

Offsite Collection Instructions

Send within 24 hours or Refrigerate/ send within 72 hours

UCMC Collection Instructions

Send within 72 hours

Test Limitations

Copy number alterations will not be detected. Assay
sensitivity
is 0.2% MAF
(one mutant molecule in a
background of 500 normal molecules).

Fee Code

376540-30081310

STAT Turnaround Time

Not Available

Container/Tube

Lavender top

Specimen Minimum Volume

1 mL

Special Instructions

Send within 72 hours

Day(s) Performed

Monday – Friday, 8:00 AM – 4:30 PM

STAT DAY(S) AND TIME(S) PERFORMED

No

CPT

81310

Method Name

Next Generation Sequencing

Reference Values

Interpretative report

Reject Due To

Inappropriate anticoagulant and >72 hours

Pediatric Volume

1 mL

Transport Instructions

Send within 24 hours or Refrigerate/ send within 72 hours

Synonyms/Key Search Words

NPM