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Test Code NPM NPM1 Mutation Analysis (Blood)

Important Note

Starting on 05/22/2017, the University of Chicago Molecular Pathology Laboratory launched a new NGS assay for the detection of mutations in Exon 11 of NPM1 gene. This test replaces the previous fragment analysis based qualitative assay and has a much improved analytical sensitivity (0.2% vs 5%).  

 

Additional Codes

n/a

Specimen Type

Blood

Container/Tube

Lavender top

Offsite Collection Instructions

Send within 24 hours or Refrigerate/ send within 72 hours

Turnaround Time

10 Days

Test Includes

Detects NPM1 insertion mutations in Exon 11

Preferred Volume

3 mL

Test Usage

May be used to monitor low level residual disease in acute
myeloid leukemia (AML) patients.

Synonyms

NPM

UCMC Collection Instructions

Send within 72 hours

Test Limitations

Copy number alterations will not be detected. Assay
sensitivity
is 0.2% MAF
(one mutant molecule in a
background of 500 normal molecules).

Fee Code

376540-30081310

STAT Turnaround Time

Not Available

Specimen Stability

72 Hours

Specimen Minimum Volume

1 mL

Special Instructions

Send within 72 hours

DAY(S) AND TIME(S) PERFORMED

Monday – Friday, 8:00 AM – 4:30 PM

STAT DAY(S) AND TIME(S) PERFORMED

No

CPT

81310

Method Name

Next Generation Sequencing

Reference Values

Interpretative report

Reject Due To

Inappropriate anticoagulant and >72 hours