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The University of Chicago Medicine Laboratories

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Mayo Clinic Laboratories

Test Code LABTXMPW (Test code: 858041) Matched Platelet Workup

Ordering Notes

Order for Matched Platelet Workup will reflex to HLA Typing and HLA Antibody Testing

Specimen and Container/Tube

See requirements for HLA Typing and HLA Antibody Testing

Volume

See requirements for HLA Typing and HLA Antibody Testing

Specimen Stability

See requirements for HLA Typing and HLA Antibody Testing

Collection Instructions

Collect specimen per standard laboratory collection procedures.

Specimen Handling and Transport Instructions

UCM Onsite Instructions: Collect specimen per standard collection procedures and send to the laboratory immediately.
UCM Offsite and UC MedLab Outreach Instructions: Collect specimen per standard collection procedures and send to the laboratory using standard transport procedures.

Rejection Criteria

See requirements for HLA Typing and HLA Antibody Testing

Reference Values

No reference range; results may be provided in an interpretive report.

Critical Values

Not Applicable

Turnaround Time

Turnaround times are relative to the time the specimen is received in the testing laboratory section.

STAT Turnaround Time: 2 business days
Routine Turnaround Time: 10 business days

If test results are needed same-day, please contact the laboratory at 2-0700, and page #8722.

Testing Schedule: M-F 7:00am-7:00pm

Clinical Indications

Platelet transfusion support: Patients with low platelet counts are at risk for serious bleeding complications and are often transfused with platelets from healthy donors. However, patients can sometimes produce antibodies to the HLA molecules expressed on platelets, which reduce the effectiveness of platelet transfusion. HLA typing, in addition to antibody detection, help physicians choose a platelet donor that will result in increased platelet counts for patients in need.

Test Components

HLA Typing and HLA Antibody Testing

CPT Codes

Low Resolution HLA Typing:
HLA Class I (A, B, C): 81372

HLA Antibody Testing:
HLA antibody screen (Class I): 86829

HLA antibody screening/identification (Class I): 86830

HLA antibody specificity (Class I): 86832

Adsorption or other serum treatment(s) may apply

Methodology

Low resolution HLA typing: Reverse sequence specific oligonucleotide probing (rSSOP)

HLA antibody testing: solid-phase and/or flow cytometry

Synonyms/Key Search Words

HLA, MPW, Matched, Platelet

Last Review Date

10/16/2024