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HelpLactate Dehydrogenase, Isoenzymes
Specimen and Container/Tube
Serum separator tube (SST) or plain red.
Specimen Stability
After separation of cells: Ambient: 1 week; Refrigerated: Unacceptable; Frozen: Unacceptable
Collection Instructions
Do not refrigerate or freeze. Allow specimen to clot completely at room temperature. Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP standard transport tube. (Min: 0.6 mL)
Specimen Handling and Transport Instructions
Room temperature.
Reference Values
Reference Interval
LD-1: 14-27%
LD-2: 29-42%
LD-3: 18-30%
LD-4: 8-15%
LD-5: 6-23%
Lactate Dehydrogenase, Total:
0-1 month: 200-465 U/L
2-17 months: 200-450 U/L
18 months-10 years: 165-430 U/L
11-16 years: 127-287 U/L
17 years and older: 105-230 U/L
Clinical Indications
Do not use to detect myocardial injury. In rare cases, this test may be used to evaluate elevated lactate dehydrogenase associated with noncardiac muscle injury. Troponin testing is recommended for diagnosis and management of acute coronary syndrome
LOINC Codes
2536-1
2539-5
2542-9
2545-2
2548-6
14804-9
Methodology
Quantitative Enzymatic Assay/Electrophoresis
Additional Information
LD-1 and LD-2 are elevated in hemolyzed specimens and serum which has not been separated from cells. LD-3, LD-4, and LD-5 are labile at low temperatures, and are erroneously low in specimens that have been refrigerated or frozen.
CPT Code(s)
83625; 83615
Turnaround Time
Performed: Sun-Sat
Reported: 1-3 days
Volume
Preferred Volume: 1 mL serum
Specimen Minimum Volume: 0.6 mL
Rejection Criteria
Hemolyzed specimens
Synonyms
- Lactate Dehydrogenase Isoenzymes, S
- LD
- LDH
- LDH Fractionation
- LDH Isoenzymes
- Isoenzymes
- Isoenzymes of Lactate Dehydrogenase
- Isoenzymes, LD
Test components
Lactate Dehydrogenase - 1
Lactate Dehydrogenase - 2
Lactate Dehydrogenase - 3
Lactate Dehydrogenase - 4
Lactate Dehydrogenase - 5
Lactate Dehydrogenase, Total
Performing Laboratory
ARUP Laboratories
500 Chipeta Way
Salt Lake City, UT 84108-1221
- Phone: 1-801-583-2787
- Toll-Free Phone: 1-800-242-2787
- Fax: 1-800-522-2706