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The University of Chicago Medicine Laboratories

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Mayo Clinic Laboratories

Test Code CPK Creatine Kinase (CK), Total

Specimen and Container/Tube

Specimen Type: Plasma

Preferred Specimen: Li-Heparin Mint Green Top

Other Acceptable specimens: Serum/Gold Top, Serum/Red Top

Volume

Preferred Volume: 0.5 mL

Minimum Volume: 0.2 mL

Specimen Stability

Storage Temperature

Stability

Room Temperature

2 days

Refrigerated

7 days

Frozen

4 weeks

 

 

Collection Instructions

Collect specimen per standard laboratory collection procedures. 

 

Specimen Handling and Transport Instructions

UCMC Onsite Instructions: 

  • Collect specimen per standard collection procedure and send to laboratory immediately. 

 

UCMC Offsite and UC MedLab Outreach Instructions: 

  • Samples should be centrifuged within 2 hours of collection.
  • Centrifuge specimens at >2500 x g for 10 minutes at room temperature.
  • Aliquot sample into plastic transport tube containing a minimum of 0.2 mL of specimen.
  • Samples must be sent refrigerated at 15-25oC.

Rejection Criteria

  • Common specimen rejected situations include: incorrect specimen type, insufficient volume, missing or incomplete specimen identifiers, incorrect specimen transport, or specimens outside stability limits. 
  • Specimens that are clotted or grossly hemolyzed.
  • Specimens that were transported unspun/whole blood and draw time is greater than 6 hours

Reference Values

Test

Age

Sex

Reference Range

Creatine Kinase

All

All

9 - 185 U/L

Note: Reference range based on in-house studies, recommendations from Tietz Textbook of Clinical Chemistry, and Roche product literature. 

Critical Values

Not applicable 

Turnaround Time

Turnaround times are relative to the time the specimen is received in the test laboratory. 

 

STAT Turnaround Time: 1 hour

Routine Turnaround Time: 4 hours

Testing Schedule:  24/7

Clinical Indications

The determination of CK and CK-isoenzyme activities is utilized in the diagnosis and monitoring of myocardial infarction and myopathies such as the progressive Duchenne muscular dystrophy.

Test Components

Creatine Kinase

Methodology

Spectrophotometric (Activation by NAC) (Roche Diagnostics)

CPT Codes

82550

LOINC Codes

2157-6

Synonyms/Keyword Search

CK, CPK, Creatine Phosphokinase

Additional Information

  • Results should always be assessed in conjunction with patient's medical history, clinical examination and other findings.
  • Following injury to the myocardium, such as occurs with acute myocardial infarcation, CK is released from the damaged myocardial cells. In early cases, a rise in the CK-activity can be found just 4 hours after an infarction. The CK-activity reaches a maximum after 12-24 hours and then falls back to the normal range after 3-4 days.
  • Cyanokit (hydroxocobalamin) at therapeutic concentrations interferes with the result.
  • CK varies with physical activity level and race in healthy individuals.

Last Review Date

8/19/2024

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