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Test Code CL Chloride

Specimen and Container/Tube

Specimen Type: Plasma

Preferred Specimen: Li-Heparin Mint Green Top

Other Acceptable specimens: Serum/Gold Top, Serum/Red Top

Specimen Handling and Transport Instructions

UCMC Onsite Instructions: 

Collect specimen per standard collection procedure and send to laboratory immediately. 

 

UCMC Offsite and UC MedLab Outreach Instructions: 

  • Samples should be centrifuged within 2 hours of collection.
  • Centrifuge specimens at >2500 x g for 10 minutes at room temperature.
  • Aliquot sample into plastic transport tube containing a minimum of 0.2 mL of specimen.
  • Samples must be sent room temperature at 15-25oC.

Rejection Criteria

  • Common specimen rejected situations include: incorrect specimen type, insufficient volume, missing or incomplete specimen identifiers, incorrect specimen transport, or specimens outside stability limits. 
  • Specimens that are clotted or grossly hemolyzed.
  • Specimens that were transported unspun/whole blood and draw time is greater than 6 hours.

Reference Values

 

Test

Age

Sex

Reference Range

Chloride

All

All

95-108 mmol/L

Anion Gap

All

All

6-15 mmol/L

Note: Reference range based on in-house studies, recommendations from Tietz Textbook of Clinical Chemistry, and Roche product literature. 

Critical Values

Analyte

Unit

Low

High

Age

N/A

N/A

N/A

N/A

N/A

CPT Codes

82435

LOINC Codes

2075-0

Volume

Preferred Volume: 0.5 mL

Minimum Volume: 0.2 mL

Specimen Stability

Storage Temperature

Stability

Room temperature

7 days

Refrigerated

7 days

Frozen

stable

Collection Instructions

Collect specimen per standard laboratory collection procedures. 

 

Test Components

Chloride

Anion Gap (IGAP) is a calculation of Sodium (Na+ ) minus ((Cl-) plus the Bicarbonate (CO2))

Clinical Indications

Chloride measurements are used in the diagnosis and treatment of electrolyte and metabolic disorders such as cystic fibrosis and diabetic acidosis.

Methodology

Ion Specific Electrode Method (ISE) (Roche Diagnostics)

Additional Information

  • Results should always be assessed in conjunction with patient's medical history, clinical examination and other findings.
  • Chloride results can be used in conjuction with sodium and bicarbonate results to provide a calculated anion gap which serves as an estimate of unmeasured anions in plasma and serum. The gap is generally elevated in renall failure, ingestion of methanol or ethylene glycol, elevated lactate or ketones and salicylate toxicity. The anion gap has been observed to be low in settings of hyopalbuminemia, hypergammaglobulnemia, hypercalcemia and hypermanesemia.
  • Hyperchloremia may be seen with: hyperventilation, dehydration, large doses of KCl or ammonium chloride, hyperparathyroidsm, rickets, cystic fibrosis, renal tubular acidosis, chronic pyelonephritis, heat stroke and exercise.
  • Hypochloremia may be seen with: hypoventilation, protracted vomiting, chronic diarrhea, diabetic ketoacidosis, lactic acidosis, adrenal disease, renal failure, acute intermittent porphyria, and congestive heart failure.
  • Also included in Basic Metabolic Panel KPNL, Comprehensive Metabolic Panel CPNL, ER Panel I STKG, Renal Function Panel RPNL, CMP for chronic lymphocytic leukemia (CPNL FOR CLL PATIENTS ONLY) SSTCP, BMP for chronic lymphocytic leukemia (KPNL FOR CLL PATIENTS ONLY)  SSTKP and Electrolyte Panel LYTS 

Turnaround Time

Turnaround times are relative to the time the specimen is received in the test laboratory. 

 

STAT Turnaround Time: 1 hour

Routine Turnaround Time: 4 hours

Testing Schedule: 24/7

Synonyms/Keyword Search

N/A

Last Review Date

8/19/2024

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