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Test Code CCLR Creatinine Clearance

Specimen and Container/Tube

Specimen Type: Plasma & Urine

 

Preferred Specimen (Plasma): Li-Heparin Mint Green Top

Other Acceptable specimens (Serum): Serum/Gold Top, Serum/Red Top

 

Preferred Specimen (Urine): Sterile 24 Hour Urine Collection Container, No Preservatives

Other Acceptable specimens (Urine): None

 

Specimen Handling and Transport Instructions

UCMC Onsite Instructions: 

  • Collect specimen per standard laboratory collection procedures. 
  • Record on the urine container the start and stop time of the 24 hour urine collection.
  • Blood sample must be collected either within 2 days of the start of the 24 hour urine collection, or 2 days after the 24 hour urine collection has ended. Order Code CREX
  • Urine container should be refrigerated during collection.
  • Urine container should be dropped off at the lab within 1 day after completion.
  • If 24 hour urine must be collected with a preservative for other analytes, only hydrocholric acid (14 to 47 mmol/L urine, e.g. 5 mL 10% HCl or 5 mL 30% HCl per liter urine) or boric acid (81 mmol/L, e.g. 5 g per liter urine) may be used.

 

 

UCMC Offsite and UC MedLab Outreach Instructions: 

  • Samples should be centrifuged within 2 hours of collection
  • Centrifuge specimens at >2500 x g for 10 minutes at room temperature.
  • Aliquot sample into plastic transport tube containing a minimum of 0.2 mL of specimen.
  • Samples must sent refrigerated at 2-8oC.
  • Record on the urine transport tube the start and stop time of the 24 hour urine collection.
  • Blood sample should be sent to UCMC at the same time as the Urine Collection to avoid cancellation of test.

Rejection Criteria

  • Common specimen rejected situations include: incorrect specimen type, insufficient volume, missing or incomplete specimen identifiers, incorrect specimen transport, or specimens outside stability limits. 
  • Specimens that are clotted or grossly hemolyzed.
  • Specimens that were transported unspun/whole blood and draw time is greater than 6 hours.
  • No information on start and stop time for 24 hour urine collection.
  • No blood sample drawn 2 days before or 2 days after timed urine collection.

Reference Values

 

Test

Age

Sex

Reference Range

Creatinine, Plasma/Serum

All

All

0.5 - 1.4 mg/dL

 

Test

Age

Sex

Reference Range

Creatinine Clearance, Urine

Male

All

85-125 mL/min

Creatinine Clearance, Urine

Female

All

75-115 mL/min

Note: Higher values in children and during pregnancy. 

Note: Reference range based on in-house studies, recommendations from Tietz Textbook of Clinical Chemistry, and Roche product literature.

Critical Values

Analyte

Unit

Low

High

Age

N/A

N/A

N/A

N/A

N/A

CPT Codes

82565, 82575

LOINC Codes

2160-0, 58446-6

Volume

Preferred Volume: 0.5 mL for Plasma/Serum

Minimum Volume: 0.2 mL for Plasma/Serum

Urine Collection is a Time Collection over a full 24 hour period. Start and Stop time should be noted on the collection container. After completion, the container should be dropped off at the lab within 1 day of completion.

Specimen Stability

Storage Temperature

Plasma/Serum Stability

Room temperature

7 days

Refrigerated

7 days

Frozen

3 months

 

Storage Temperature

Urine Stability

Room temperature

2 days

Refrigerated

6 days

Frozen

6 months

Collection Instructions

  • Collect specimen per standard laboratory collection procedures. 
  • Record on the urine container the start and stop time of the 24 hour urine collection.
  • Blood sample must be collected either within 2 days of the start of the 24 hour urine collection, or 2 days after the 24 hour urine collection has ended.
  • Urine container should be refrigerated during collection.
  • Urine container should be dropped off at the lab within 1 day after completion.
  • If 24 hour urine must be collected with a preservative for other analytes, only hydrocholric acid (14 to 47 mmol/L urine, e.g. 5 mL 10% HCl or 5 mL 30% HCl per liter urine) or boric acid (81 mmol/L, e.g. 5 g per liter urine) may be used.

Test Components

Creatinine, Plasma/Serum (Order Code CREX)
Creatinine, Urine
Creatinine Clearance Calculation

Clinical Indications

Used to assess renal function.

Methodology

Enzymatic Method (Roche Diagnostics)

Additional Information

  • Results should always be assessed in conjunction with patient's medical history, clinical examination and other findings.
  • Blood should be collected during the urine collection duration to provide accurate creatinine clearance results..
  • The presence of ketone bodies can cause artifically high results in urine. High homogentisic acid concentrations in urine samples lead to false results.
  • Results from samples that are not collected over a full 24 hour period may be subject to certain inaccuracies.

Turnaround Time

Turnaround times are relative to the time the specimen is received in the test laboratory. 

 

STAT Turnaround Time: Not available as STAT test

Routine Turnaround Time: 4 hours

Testing Schedule: 24/7

Synonyms/Keyword Search

N/A

Last Review Date

8/19/2024

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