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HelpTest Code CCLR Creatinine Clearance
Specimen and Container/Tube
Specimen Type: Plasma & Urine
Preferred Specimen (Plasma): Li-Heparin Mint Green Top
Other Acceptable Specimens (Serum): Serum/Gold Top, Serum/Red Top
Preferred Specimen (Urine): Sterile 24 Hour Urine Collection Container, No Preservatives
Other Acceptable Specimens (Urine): None
Volume
Preferred Volume: 0.5 mL for Plasma/Serum
Minimum Volume: 0.2 mL for Plasma/Serum
Urine Collection is a Time Collection over a full 24 hour period. Start and Stop time should be noted on the collection container. After completion, the container should be dropped off at the lab within 1 day of completion.
Specimen Stability
|
Storage Temperature |
Plasma/Serum Stability |
|
Room temperature |
7 days |
|
Refrigerated |
7 days |
|
Frozen |
3 months |
|
Storage Temperature |
Urine Stability |
|
Room temperature |
2 days |
|
Refrigerated |
6 days |
|
Frozen |
6 months |
Collection Instructions
- Collect specimen per standard laboratory collection procedures.
- Record on the urine container the start and stop time of the 24 hour urine collection.
- Blood sample must be collected either within 2 days of the start of the 24 hour urine collection, or 2 days after the 24 hour urine collection has ended.
- Urine container should be refrigerated during collection.
- Urine container should be dropped off at the lab within 1 day after completion.
- If 24 hour urine must be collected with a preservative for other analytes, only hydrocholric acid (14 to 47 mmol/L urine, e.g. 5 mL 10% HCl or 5 mL 30% HCl per liter urine) or boric acid (81 mmol/L, e.g. 5 g per liter urine) may be used.
Specimen Handling and Transport Instructions
UCMC Onsite Instructions:
- Collect specimen per standard laboratory collection procedures.
- Record on the urine container the start and stop time of the 24 hour urine collection.
- Blood sample must be collected either within 2 days of the start of the 24 hour urine collection, or 2 days after the 24 hour urine collection has ended. Order Code CREX
- Urine container should be refrigerated during collection.
- Urine container should be dropped off at the lab within 1 day after completion.
- If 24 hour urine must be collected with a preservative for other analytes, only hydrocholric acid (14 to 47 mmol/L urine, e.g. 5 mL 10% HCl or 5 mL 30% HCl per liter urine) or boric acid (81 mmol/L, e.g. 5 g per liter urine) may be used.
UCMC Offsite and UC MedLab Outreach Instructions:
- Samples should be centrifuged within 2 hours of collection
- Centrifuge specimens at >2500 x g for 10 minutes at room temperature.
- Aliquot sample into plastic transport tube containing a minimum of 0.2 mL of specimen.
- Samples must sent refrigerated at 2-8oC.
- Record on the urine transport tube the start and stop time of the 24 hour urine collection.
- Blood sample should be sent to UCMC at the same time as the Urine Collection to avoid cancellation of test.
Rejection Criteria
- Common specimen rejected situations include: incorrect specimen type, insufficient volume, missing or incomplete specimen identifiers, incorrect specimen transport, or specimens outside stability limits.
- Specimens that are clotted or grossly hemolyzed.
- Specimens that were transported unspun/whole blood and draw time is greater than 6 hours.
- No information on start and stop time for 24 hour urine collection.
- No blood sample drawn 2 days before or 2 days after timed urine collection.
Reference Values
|
Test |
Age |
Sex |
Reference Range |
|
Creatinine, Plasma/Serum |
All |
All |
0.5 - 1.4 mg/dL |
|
Creatinine Clearance, Urine |
Male |
All |
85-125 mL/min |
|
Creatinine Clearance, Urine |
Female |
All |
75-115 mL/min |
Note: Higher values in children and during pregnancy.
Note: Reference range based on in-house studies, recommendations from Tietz Textbook of Clinical Chemistry, and Roche product literature.
Critical Values
Not applicable
Turnaround Time
Turnaround times are relative to the time the specimen is received in the test laboratory.
STAT Turnaround Time: Not available as STAT test
Routine Turnaround Time: 4 hours
Testing Schedule: 24/7
Clinical Indications
Used to assess renal function.
Test Components
Urine collection duration, Urine total volume, Serum Creatinine, Urine Creatinine Random, Urine Creatinine Timed, Creatinine Clearance
Methodology
Enzymatic Method (Roche Diagnostics)
CPT Codes
82565, 82575
LOINC Codes
2160-0, 58446-6
Synonyms/Keyword Search
N/A
Additional Information
- Results should always be assessed in conjunction with patient's medical history, clinical examination and other findings.
- Blood should be collected during the urine collection duration to provide accurate creatinine clearance results..
- The presence of ketone bodies can cause artifically high results in urine. High homogentisic acid concentrations in urine samples lead to false results.
- Results from samples that are not collected over a full 24 hour period may be subject to certain inaccuracies.
Last Review Date
8/19/2024