Ordering Guidance

Typically, physicians will order acetylcholine receptor (AChR) binding, blocking, and modulating antibodies. Mayo Clinic Laboratories' (MCL) tests are not named in that manner; instead these are offered as myasthenia gravis (MG) evaluations. MGMR / Myasthenia Gravis Evaluation with Muscle-Specific Kinase (MuSK) Reflex, Serum is the testing of choice in most cases.

AChR blocking antibody testing is no longer offered individually as it offers no added-value to the diagnosis and management of MG.

Specimen Required

Only orderable as part of a profile. For more information see:

MGLE / Myasthenia Gravis/Lambert-Eaton Myasthenic Syndrome Evaluation, Serum

MGMR / Myasthenia Gravis Evaluation with Muscle-Specific Kinase (MuSK) Reflex, Serum

PAVAL / Paraneoplastic, Autoantibody Evaluation, Serum

Collection Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.