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Test Code IGMN Neonate IgM (Cord or Neonate Blood)

Specimen and Container/Tube

Plasma

Rejection Criteria

Whole blood/unspun samples greater than 6 hours will be
rejected.

Turnaround Time

N/A

Test Includes

N/A

Specimen Type

Plasma

Preferred Volume

0.5 mL

Critical Results

N/A

Test Limitations

It is known that the so-called paraproteins secreted in
monoclonal gammopathies (monoclonal immunoglobulinemia) may
differ
from the respective immunoglobulins of polyclonal origin by
amino
acid composition and size. This may impair the binding to
antibody
and hence impair accurate quantitation.

Fee Code

43059

Container/Tube

Li-Heparin  Mint Green Top

Specimen Minimum Volume

0.2 mL

Day(s) Performed

24 hours, 7 days a week including holidays

STAT DAY(S) AND TIME(S) PERFORMED

N/A

CPT

82784

Method Name

Immunoturbidimetric Assay

Reference Values

In cord blood:?�?�?� 11-35 mg/dL?�
Up to 1 month:?�?� 12-87 mg/dL

Reject Due To

Whole blood/unspun samples greater than 6 hours will be
rejected.

STAT Turnaround Time

N/A

Synonyms

N/A

Test Usage

Increased polyclonal IgM levels are found in viral, bacterial,
and parasitic infections, liver diseases, rheumatoid arthritis,
scleroderma, cystic fibrosis and heroin addiction. Monoclonal IgM
is increased in Waldenström’s macroglobulinemia.
Increased loss of IgM is found in protein-losing enteropathies and
in burns.

Decreased synthesis of IgM occurs in congenital and acquired
immunodeficiency syndromes. Due to the slow onset of IgM synthesis,
the IgM concentration in serum from infants is lower than in that
from adults.

Offsite Collection Instructions

1. Collect sample following standard collection methods
2. Within 2 hours of collection the sample must be spun and
aliquoted
3. Transport refrigerated  (2 – 8C).

UCMC Collection Instructions

1. Collect sample following standard collection methods
2. Within 2 hours of collection the sample must be received in
Laboratory Service Center
3. Transport room temperature (15 – 25C).

Additional Information

N/A

Included in Additional codes

N/A

Coverage Information

N/A

Stability: Room Temp

2 months

Stability: Refrigerated

4 months

Stability: Frozen

6 months

Pediatric Volume

0.2 mL

Clinical Indications

Increased polyclonal IgM levels are found in viral,
bacterial,
and parasitic infections, liver diseases, rheumatoid arthritis,
scleroderma, cystic fibrosis and heroin addiction. Monoclonal
IgM
is increased in Waldenstrm�s macroglobulinemia.
Increased loss of IgM is found in protein-losing enteropathies
and
in burns.

Decreased synthesis of IgM occurs in congenital and acquired
immunodeficiency syndromes. Due to the slow onset of IgM
synthesis,
the IgM concentration in serum from infants is lower than in
that
from adults.

Transport Instructions

1. Collect sample following standard collection methods
2. Within 2 hours of collection the sample must be spun and
aliquoted
3. Transport?�refrigerated?�?�(2 �?? 8C).

Test Components

N/A

Specimen Stability

2 months

Methodology

Immunoturbidimetric Assay

Synonyms/Key Search Words

N/A