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Test Code CGPR CHROMOSOME ANALYSIS WITH REFLEX TO CYTOGENOMIC SNP ARRAY, AMNIOTIC FLUID

Important Note

Please call the lab at 2-6203 for any ordering questions and for sample pick up as soon as specimen is collected.

Specimen and Container/Tube

Specimen:  Amniotic fluid

Containter/Tube:  Sterile 15ml conical tubes or Sterile specimen cup (will be provided by the lab if needed.  Call 2-6203)

Please DO NOT collect specimen in a specimen cup with a hole in the lid.

Rejection Criteria

>72 hours after collection

Reference Values

Interpretative Report

Critical Values

N/A

Turnaround Time

N/A

CPT Codes

88235; 88262; 88280; 81229

Volume

Preferred:    >40ml of Amniotic Fluid                                                        

Amount needed by test:      

*Chromosome Analysis:  10-15 mL                                       *SNP Array (direct): 15mL           

*FISH:  5 mL                                                                              *AFP, *CMV, *Toxo:  1 mL each test                

Last Review Date

10/24/2022 RB

Collection Instructions

Amniotic fluid should be collected in sterile 15mL conical tubes (provided by the lab).  Keep at room temperature.   If specimen will sit for more than 24 hrs, please refrigerate at 4°C until specimen can be picked up by the laboratory

Additional Information

SNP Array Test Limitations:  Will not detect balanced translocations, low level mosaicism, some instances of uiparental disomy, point mutations and small insertion/deletions.

LOINC

N/A

Specimen Stability

Keep at room temperature and deliver to the lab within 24 hours.  If specimen will sit for more than 24 hrs, please refrigerate at 4°C until specimen can be picked up by the laboratory

Clinical Indications

Indication for prenatal chromosome analysis with reflex to SNP array include: pregnancies at increased risk for fetal chromosome abnormality based on family history or maternal age, abnormal noninvasive prenatal testing (NIPT), abnormal multiple marker screening, or abnormal fetal ultrasound; clarification of ambiguous chromosome results; detection of chromosomal rearrangements.

Specimen Handling & Transport Instructions

Once the specimen is collected, the laboratory should be called at 2-6203 for sample pickup.  

Amniotic Fluid specimens should NOT be tubed!

Test Components

Tissue Culture; limited chromosome analysis; karyotype with reflex to SNP array if chromosomes are normal

Methodology

Chromosome Analysis

SNP Microarray

Synonyms/Key Search Words

Microarray, SNP, gen hyb, ACGH, Gene, Whole Gene, CGH