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Test Code CGOR CHROMOSOME ANALYSIS WITH REFLEX TO CYTOGENOMIC SNP ARRAY, PRODUCTS OF CONCEPTION

Important Note

Preferred Specimen:  Chorionic Villi/Placenta 

Specimen cannot be processed if Formalin fixed.

 

Specimen and Container/Tube

Products of conception (Chorionic villi) or other fetal tissues collected in a sterile specimen cup w/ transport media (provided by the lab) or sterile saline.

Please DO NOT use specimen cups with a hole in the lid.  Media/specimen will leak during transport.

Rejection Criteria

Formalin fixed tissue cannot be processed by the laboratory;

Non-pregnancy tissue (at the discretion of the section director or supervisor)

Reference Values

Interpretative Report

Critical Values

N/A

Turnaround Time

N/A

LOINC Codes

N/A

Last Review Date

10/24/2022 RB

CPT Code

88233; 88262; 81229

Volume

Preferred:  100+mg of tissue

Minimum:  40mg of tissue

Specimen Handling & Transport Instructions

Refrigerate at 4°C and deliver to laboratory within 24 hours of specimen collection.  

POC speimen can be tubed to J-601  (Tube station #461)

Additional Information

SNP Array Test Limitations:  Will not detect balanced translocations, low level mosaicism, some instances of uiparental disomy, point mutations and small insertion/deletions.

Clinical Indications

Indication for chromosome analysis with reflex to SNP array testing of products of conception include:
pregnancy loss of unknown etiology; fetal anomalies; parental chromosome abnormality; clarification of ambiguous chromosomal findings; detection of chromosome rearrangements; failiure of
tissue to grow in culture.

Specimen Stability

Refrigerate at 4°C and deliver to laboratory within 24 hours of specimen collection.  

Test Components

Tissue Culture; limited chromosome analysis; karyotype with reflex to SNP array if chromosomes are normal

Collection Instructions

Specimen should be collected in a sterile specimen cup with transport media (provided by the lab) or sterile saline.  Refrigerate at 4°C and deliver to laboratory within 24 hours of specimen collection.  

Please DO NOT wrap tissue in guaze!

Methodology

Chromosome Analysis;  SNP Microarray

Synonyms/Search Keyword

Microarray, SNP, gen hyb, ACGH, Gene, Whole Gene, CGH