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Test Code CGCR CHROMOSOME ANALYSIS WITH REFLEX TO CYTOGENOMIC SNP ARRAY, CHORIANIC VILLI

Important Note

Please call the lab at 2-6203 for any ordering questions and for sample pick up.  

*A maternal blood sample collected in an EDTA tube should also be submitted at the time of CVS collection.  This blood will be used for possible future MCC studies.  

Specimen and Container/Tube

Chorionic villus collected in a sterile specimen cup with transport media (provided by the laboratory).  Arrangements for media should be made prior to sample collection.  Please call 2-6203 for media.

Specimen Handling and Transport Instructions

Once the specimen is collected, the laboratory should be called at 2-6203 for sample pickup.  CVS specimens should NOT be tubed!

Rejection Criteria

>72 hours after collection

Reference Values

Interpretative Report

Critical Values

N/A

Turnaround Time

N/A

CPT Codes

88235;     88262;      88280;    81229

LOINC Codes

N/A

Volume

Preferred:    >40mg                                                        

Amount needed by test:                        

 Chromosome Analysis:  15-20 mg                   AneuVysion:  5 mg                              SNP Array (direct): 15-20mg             

Collection Instructions

Specimen should be collected in a sterile specimen cup with transport media (provided by the lab).  Keep at room temperature until sample is collected by the lab. 

Last Review Date

11/14/2022 RB

Additional Information

SNP Array Test Limitations:  Will not detect balanced translocations, low level mosaicism,
some instances of uiparental disomy, point mutations and small insertion/deletions.

Specimen Stability

Keep at room temperature and deliver to the lab within 24 hours.  

If specimen will sit for more than 24 hrs, please refrigerate at 4°C until specimen can be picked up by the laboratory

Clinical Indications

Indication for prenatal chromosome analysis with reflex to SNP array include: pregnancies at increased risk for fetal chromosome abnormality based on family history or maternal age, abnormal noninvasive prenatal testing (NIPT),
abnormal multiple marker screening, or abnormal fetal ultrasound; clarification of ambiguous chromosome results; detection of chromosomal rearrangements.

Test Components

Tissue Culture; limited chromosome analysis; karyotype with reflex to SNP array if chromosomes are normal

Methodology

Chromosome Analysis;  SNP Microarray

Synonyms/Key Search Words

Microarray;  SNP;  gen hyb;  ACGH;  Gene;  Whole Gene;  CGH