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Test Code CGAF Chromosome Analysis, prenatal, amniotic fluid

Important Note

Please call the lab at 2-6203 for any ordering questions and for sample pick up.

Specimen and Container/Tube

Amniotic fluid in a sterile 15ml conical tube (can be provided by the laboratory)

Please DO NOT use dark AMBER tubes for AF collection

Rejection Criteria

>72 hours after collection

Reference Values

Interperative Report

Critical Values

N/A

Turnaround Time

N/A

CPT Codes

88235, 88267, 88280

LOINC Codes

N/A

Collection Instructions

Amniotic fluid should be collected in sterile 15mL conical tubes (provided by the lab).  Keep at room temperature.   If specimen will sit for more than 24 hrs, please refrigerate at 4°C until specimen can be picked up by the laboratory

Additional Information

Test Limitations:  Will not detect submicroscopic or molecular mutations, chromosomal abnormalities below the stated resolution, or low levels of mosicism.

Last Review Date

12/8/2022

Specimen Stability

Keep at room temperature and deliver to the lab within 24 hours.  If specimen will sit for more than 24 hrs, please refrigerate at 4°C until specimen can be picked up by the laboratory

Volume

Preferred:    >15ml                                                        

Amount needed by test:    

Chromosomes:  10-15 mL                AneuVysion (FISH):  5 mL         AFP, CMV, Toxo, etc:  1ml for each test ordered                          

Clinical Indications

Prenatal chromosome analysis is appropriate when an individual is at increased risk for fetal aneuploidy based on:  maternal age; abnormal noninvasive prenatal testing (NIPT); abnormal multiple marker screening; or abnormal fetal ultrasound or has a family history of chromosome abnormality or genetic disorder.

Specimen Handling & Transport Instructions

Once the specimen is collected, the laboratory should be called at 2-6203 for sample pickup.  

Amniotic Fluid specimens should NOT be tubed!

Test Components

Tissue Culture; Chromosome analysis; Karyotype

Methodology

Culture and Giemsa Band

Synonyms/Key Search Words

Karyotype