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Test Code VANTR Vancomycin, Trough

Specimen Type

Serum

Container/Tube

Red Top

Offsite Collection Instructions

1. Collect sample following standard collection methods
2. Recommended that serum should be drawn 30 minutes prior to next dose
3. Within 2 hours of collection the sample must be spun and aliquoted
4. Transport refrigerated  (2 – 8˚C).

Turnaround Time

4 hours

Test Includes

N/A

Preferred Volume

0.5 mL

UCMC Collection Instructions

1. Collect sample following standard collection methods
2. Recommended that serum should be drawn 30 minutes prior to next dose
3. Within 2 hours of collection the sample must be received in Laboratory Service Center
4. Transport room temperature (15 – 25˚C)

Test Usage

The measurement of vancomycin concentrations in serum is essential to optimize therapy and avoid dosage related toxicity.
This is especially important in patients with renal insufficiency, where individualized patient therapy is the only method to ensure optimal therapeutic serum levels without serious side effects.

Critical Results

Adults: >20 µg/mL

Pediatric Alert Value: >20 µg/mL

Fee Code

43771

Specimen Minimum Volume

0.2 mL

DAY(S) AND TIME(S) PERFORMED

24 hours, 7 days a week including holidays

STAT DAY(S) AND TIME(S) PERFORMED

Available

CPT

80202

Method Name

Kinetic Interaction of Microparticles in solution (KIMS)

Reference Values

10 - 20 µg/mL

 

References:
1. Rybak M, Lomaestro B, Rotschafer JC, et al. Therapeutic monitoring of vancomycin in adult patients: a consensus review of the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases Pharmacists. Am J Health-Syst Pharm 2009;66:82-98.


2. University of Chicago Medical Center. Policy and Procedure Manual. PH04-001 Clinical Pharmacokinetics Service, Appendix B: Vancomycin (Adult) Dosing Guidelines, July 2019 or most recent version.

Reject Due To

Whole blood/unspun samples greater than 6 hours will be rejected.

STAT Turnaround Time

1 hour

Synonyms

N/A

Test Limitations

Serum trough concentrations, drawn at steady-state conditions, are recommended as the most accurate and practical method to monitor vancomycin therapy. Steady-state achievement is variable but more reliably occurs by the 4th dose.

Additional Information

Orders for peak concentrations are not recommended since there is little correlation between high peak levels and toxicity.

 

Please consult the ID PharmD (7945) M-F or the Inpatient Pharmacy for dosing recommendations.

Included in Additional codes

N/A

Coverage Information

N/A

Stability: Room Temp

48 hours

Stability: Refrigerated

14 days

Stability: Frozen

12 months