Test Code VANTR Vancomycin, Trough
Specimen Type
Serum
Container/Tube
Red Top
Offsite Collection Instructions
1. Collect sample following standard collection methods
2. Recommended that serum should be drawn 30 minutes prior to next
dose
3. Within 2 hours of collection the sample must be spun and
aliquoted
4. Transport refrigerated (2 – 8˚C).
Turnaround Time
4 hours
Test Includes
N/A
Preferred Volume
0.5 mL
UCMC Collection Instructions
1. Collect sample following standard collection methods
2. Recommended that serum should be drawn 30 minutes prior to next
dose
3. Within 2 hours of collection the sample must be received in
Laboratory Service Center
4. Transport room temperature (15 – 25˚C)
Test Usage
The measurement of vancomycin concentrations in serum is
essential to optimize therapy and avoid dosage related
toxicity.
This is especially important in patients with renal insufficiency,
where individualized patient therapy is the only method to ensure
optimal therapeutic serum levels without serious side effects.
Critical Results
Adults: >20 µg/mL
Pediatric Alert Value: >20 µg/mL
Fee Code
43771
Specimen Minimum Volume
0.2 mL
DAY(S) AND TIME(S) PERFORMED
24 hours, 7 days a week including holidays
STAT DAY(S) AND TIME(S) PERFORMED
Available
CPT
80202
Method Name
Kinetic Interaction of Microparticles in solution (KIMS)
Reference Values
10 - 20 µg/mL
References:
1. Rybak M, Lomaestro B, Rotschafer JC, et al. Therapeutic
monitoring of vancomycin in adult patients: a consensus review of
the American Society of Health-System Pharmacists, the Infectious
Diseases Society of America, and the Society of Infectious Diseases
Pharmacists. Am J Health-Syst Pharm 2009;66:82-98.
2. University of Chicago Medical Center. Policy and Procedure
Manual. PH04-001 Clinical Pharmacokinetics Service, Appendix B:
Vancomycin (Adult) Dosing Guidelines, July 2019 or most recent
version.
Reject Due To
Whole blood/unspun samples greater than 6 hours will be rejected.
STAT Turnaround Time
1 hour
Synonyms
N/A
Test Limitations
Serum trough concentrations, drawn at steady-state conditions, are recommended as the most accurate and practical method to monitor vancomycin therapy. Steady-state achievement is variable but more reliably occurs by the 4th dose.
Additional Information
Orders for peak concentrations are not recommended since there is little correlation between high peak levels and toxicity.
Please consult the ID PharmD (7945) M-F or the Inpatient Pharmacy for dosing recommendations.
Included in Additional codes
N/A
Coverage Information
N/A
Stability: Room Temp
48 hours
Stability: Refrigerated
14 days
Stability: Frozen
12 months