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Test Code VANTR Vancomycin, Trough in Serum

Specimen Type

Serum

Container

Red top

Preferred Volume

3 mL

Offsite Collection Instructions

Serum trough concentrations, drawn at steady-state conditions, are recommended as the most accurate and practical method to monitor vancomycin therapy. Steady-state achievement is variable but more reliably occurs by the 4th dose.

 

Serum for a trough level is usually drawn within 30 minutes prior to the next dose.

UCMC Collection Instructions

Serum trough concentrations, drawn at steady-state conditions, are recommended as the most accurate and practical method to monitor vancomycin therapy. Steady-state achievement is variable but more reliably occurs by the 4th dose.

 

Serum for a trough level is usually drawn within 30 minutes prior to the next dose.

Availability

24/7

Turnaround Time

4 hours

STAT Availability

Not Available

Test Usage

The measurement of vancomycin concentrations in serum is essential to optimize therapy and avoid dosage related toxicity. This is especially important in patients with renal insufficiency, where individualized patient therapy is the only method to ensure optimal therapeutic serum levels without serious side effects.

Test Methodology

Kinetic Interaction of Microparticles in a Solution (KIMS)

CPT Code

80202

Test Includes

Quantitative determination of vancomycin in serum

Reference Range

Trough Goals:
15 – 20 µg/mL

Ventilator Associated Pneumonia (VAP)

Hospital Acquired Pneumonia (HAP)

Meningitis

 

10 – 15 µg/mL
Endocarditis
Osteomyelitis
 

5 – 10 µg/mL
All other infections

 

Orders for peak concentrations are not recommended since there is little correlation between high peak levels and toxicity.

 

Please consult the ID PharmD (7945) M-F or the Inpatient Pharmacy for dosing recommendations.

 

References
1. Rybak M, Lomaestro B, Rotschafer JC, et al. Therapeutic monitoring of vancomycin in adult patients: a consensus review of the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases Pharmacists. Am J Health-Syst Pharm 2009;66:82-98.
2. University of Chicago Medical Center. Policy and Procedure Manual. PH04-001 Clinical Pharmacokinetics Service, Appendix B: Vancomycin (Adult) Dosing Guidelines, March 2010 or most recent version.

Critical Results

> 50 µg/mL

Minimum Volume

1 mL

Fee Code

43771