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Test Code VALP Valproic Acid

Specimen Type

Serum

Container/Tube

Red Top

Offsite Collection Instructions

Peak level:       30 min after completion of
dose
Trough level:   30 min before next dose

1. Collect sample following standard collection methods
2. Within 2 hours of collection the sample must be spun and
aliquoted
3. Transport refrigerated  (2 – 8C).

Turnaround Time

4  hours

Test Includes

N/A

Preferred Volume

0.5 mL

UCMC Collection Instructions

Peak level:       30 min after completion of
dose
Trough level:   30 min before next dose

1. Collect sample following standard collection methods
2. Within 2 hours of collection the sample must be received in
Laboratory Service Center
3. Transport room temperature (15 – 25C).

STAT Turnaround Time

1 hour

Test Usage

Useful for monitoring therapy, assessing compliance and
evaluating potential valproic acid toxicity.

Critical Results

>200 µg/mL

Test Limitations

Co-administration of other anti-epileptic drugs can
significantly affect valproic acid metabolism. Several factors
complicate interpretation of valproic acid levels, including time
interval between drug administration and blood sampling, the type
of seizures treated, albumin concentration and factors affecting
albumin binding of valproic acid , and the presence of other
anti-epileptic drugs and pharmacologically-active metabolites of
valproic acid.

Fee Code

43683

Synonyms

Depakote

Specimen Minimum Volume

0.2 mL

DAY(S) AND TIME(S) PERFORMED

24 hours, 7 days a week including holidays

STAT DAY(S) AND TIME(S) PERFORMED

Available

CPT

80164

Method Name

Homogeneous Enzyme Immunoassay Technique (EMIT)

Reference Values

therapeutic range: 50 – 100 µg/mL

Reject Due To

Whole blood/unspun samples greater than 6 hours will be
rejected.

Additional Information

N/A

Included in Additional codes

N/A

Coverage Information

N/A

Stability: Room Temp

2 days

Stability: Refrigerated

7 days

Stability: Frozen

3 months