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Test Code MAU Urine Microalbumin, Quantitative, 24 hour

Important Note

If ordering a random collection use order code RMALB

Specimen Type

Urine, Timed (24 hour)

Container/Tube

Sterile Urine Container

Offsite Collection Instructions

1. Follow clinic instructions for 24 hour collection
process.
2. Keep urine refrigerated during the 24 hour collection
process.
3. Aliquot 10 mL from a well mixed timed sample collection.
4. Indicate collection volume and duration.
5. Transport refrigerated (2-8 ° C).

Turnaround Time

4 hours

Test Includes

Quantitative determination of microalbumin in urine

Preferred Volume

1.0 mL

Specimen Minimum Volume

0.5 mL

Reject Due To

N/A

DAY(S) AND TIME(S) PERFORMED

24 hours, 7 days a week including holidays.

STAT DAY(S) AND TIME(S) PERFORMED

N/A

STAT Turnaround Time

N/A

Method Name

Immunoturbidimetric

Synonyms

N/A

CPT

RMALB: 82043

Fee Code

RMALB: 43853

Test Limitations

As there is considerable biologic variability in microalbumin
excretion, it is recommended that all patients be evaluated for
microalbuminuria based on more than an isolated determination on a
single urine specimen (regardless of whether a timed or untimed
urine specimen is used). Reports indicate that intra-individual
biologic variability may be as high as 20 – 40% over the
course of a one-month period. Moreover, various physiologic and
pathologic factors are also known to potentially alter urinary
microalbumin excretion, including: strenuous exercise, diurnal
variation, pyrexia, urinary tract infection, menstruation,
pregnancy, acute diuresis or fluid overload, hypertension,
congestive heart failure, atherosclerosis, and postural
(orthostatic) proteinuria. These factors must be taken into
consideration when assessing patients for microalbuminuria, and
before any clinical decision is made concerning the need to
institute aggressive therapy (e.g., committing patients to a
long-term course of management with ACE
inhibitor antihypertensives).

It is strongly advised that all positive test results for
microalbuminuria be confirmed by follow-up testing on two
additional urine specimens, collected on separate occasions. If a
positive result is obtained by screening an untimed (random) urine
specimen, it is preferable that the confirmatory quantitation of
microalbumin be performed using timed (24 hour) urine collections.
If confirmatory test results are consistent with microalbuminuria,
and other physiologic or pathologic factors have been excluded as
potential causes, these findings may be considered indicative of
incipient nephropathy, and only then should aggressive therapy be
considered.

Test Usage

Microalbuminuria testing is used to detect albuminuria in
diabetes mellitus, pre-eclampsia, hypertension and systemic lupus
erythematosus. Its major role is to attempt to predict subsequent
development of proteinuria, diabetic nephropathy, serious
extrarenal cardiovascular disease and early mortality in Type I
and/or Type II diabetes.

UCMC Collection Instructions

1. Follow clinic instructions for 24 hour collection
process.
2. Keep urine refrigerated during the 24 hour collection
process.
3. Aliquot 10 mL from a well mixed timed sample collection.
4. Indicate collection volume and duration.
5. Transport refrigerated (2-8 ° C).

Reference Values

Timed: <30 mg/24 hr; excretion rate: <20 ug/min

Microalbuminuria is defined as albumin excretion in the
30-300
mg/24 hr and 20-200mg/min range for timed (24 hour) urine
specimens, or albumin/creatinine ratios in the 20-200mg/mg
range
for untimed (random) specimens.

Overt albuminuria is defined as albumin excretion > 300
mg/24
hr and > 200mg/min for timed (24 hour) urine specimens, or
albumin/creatinine ratios >200 mg/mg for untimed (random)
urine
specimens.

Additional Information

N/A

Stability: Room Temp

7 days

Stability: Refrigerated

1 month

Stability: Frozen

6 months