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Test Code LIDO Lidocaine Level

Specimen Type



Red top

Preferred Volume

4 mL

UCMC Collection Instructions

Pharmacokinetic factors influence the correct time of sample collection after the last drug dose. These factors include dosage form, mode of administration, concomitant drug therapy, and biological variations affecting drug disposition.

Recommendations include draw specimens 12 hours after initiating therapy for arrhythmia prophylaxis, then every 24 hours thereafter.



Turnaround Time

3 hours

STAT Availability

Not Available

Test Methodology

homogeneous enzyme immunoassay technique (EMIT)

CPT Code


Test Includes

quantitative analysis of lidocaine in serum

Reference Range

Therapeutic range:
Adults:             1.5 – 6.0 µg/mL 

Critical Results

  >9 µg/mL

Test Limitations

  • The factors that can influence the relationship between lidocaine serum or plasma concentrations and clinical response include the severity and type of arrhythmia and heart disease, liver function, kidney function, circulatory function, age, general state of health, diet, smoking, and use of other drugs.
  • The concentration of lidocaine in serum or plasma depends on the time of the last drug dose; dosage form; mode of administration; concomitant drug therapy; sample condition; time of sample collection; and individual variations in absorption, biotransformation, distribution, and excretion. These parameters must be considered when interpreting results.
  • Results of this test should always be interpreted in conjunction with the patient’s medical history, clinical presentation and other findings.

Minimum Volume

2 mL

Fee Code