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Test Code IGM Immunoglobulin M

Specimen and Container/Tube

Plasma

Specimen Stability

2 months

Rejection Criteria

Whole blood/unspun samples greater than 6 hours will be
rejected.

Clinical Indications

Increased polyclonal IgM levels are found in viral,
bacterial,
and parasitic infections, liver diseases, rheumatoid arthritis,
scleroderma, cystic fibrosis and heroin addiction. Monoclonal
IgM
is increased in Waldenstrm�s macroglobulinemia.
Increased loss of IgM is found in protein-losing enteropathies
and
in burns.

Decreased synthesis of IgM occurs in congenital and acquired
immunodeficiency syndromes.

Test Components

N/A

Methodology

Immunoturbidimetric Assay

Additional Information

Once per admit. ?�
If monitoring an identified paraprotein, then once per week.

Test Includes

N/A

Specimen Type

Plasma

Preferred Volume

0.5 mL

UCMC Collection Instructions

1. Collect sample following standard collection methods
2. Within 2 hours of collection the sample must be received in
Laboratory Service Center
3. Transport room temperature (15 – 25C).

Turnaround Time

N/A

Critical Results

N/A

Test Limitations

It is known that the so-called paraproteins secreted in
monoclonal gammopathies (monoclonal immunoglobulinemia) may
differ
from the respective immunoglobulins of polyclonal origin by
amino
acid composition and size. This may impair the binding to
antibody
and hence impair accurate quantitation.

Fee Code

43057

Synonyms

N/A

Container/Tube

Li-Heparin  Mint Green Top

Specimen Minimum Volume

0.2 mL

Day(s) Performed

24 hours, 7 days a week including holidays.

STAT DAY(S) AND TIME(S) PERFORMED

N/A

CPT

82784

Method Name

Immunoturbidimetric Assay

Reference Values

Age?�?�?�?�?� Value (mg/dL)

> 14Y?�?� 50-320
12?�?�?�?�?�?�?�?� 70-150
11?�?�?�?�?�?�?�?� 66-155
10?�?�?�?�?�?�?�?� 80-150
9?�?�?�?�?�?�?�?�?�?�
55-160
8?�?�?�?�?�?�?�?�?�?�
68-175
7?�?�?�?�?�?�?�?�?�?�
60-175
6?�?�?�?�?�?�?�?�?�?�
55-210
5?�?�?�?�?�?�?�?�?�?�
40-180
4?�?�?�?�?�?�?�?�?�?�
52-200
3?�?�?�?�?�?�?�?�?�?�
46-190
2?�?�?�?�?�?�?�?�?�?�
72-160
7M?�?�?�?�?�?�?� 36-104
4M?�?�?�?�?�?�?� 25-120
1M?�?�?�?�?�?�?� 12-87
0?�?�?�?�?�?�?�?�?�?�
11-35

Reject Due To

Whole blood/unspun samples greater than 6 hours will be
rejected.

STAT Turnaround Time

N/A

Test Usage

Increased polyclonal IgM levels are found in viral, bacterial,
and parasitic infections, liver diseases, rheumatoid arthritis,
scleroderma, cystic fibrosis and heroin addiction. Monoclonal IgM
is increased in Waldenström’s macroglobulinemia.
Increased loss of IgM is found in protein-losing enteropathies and
in burns.

Decreased synthesis of IgM occurs in congenital and acquired
immunodeficiency syndromes.

Offsite Collection Instructions

1. Collect sample following standard collection methods
2. Within 2 hours of collection the sample must be spun and
aliquoted
3. Transport refrigerated  (2 – 8C).

Stability: Room Temp

2 months

Stability: Refrigerated

4 months

Stability: Frozen

6 months

Pediatric Volume

0.2 mL

Transport Instructions

1. Collect sample following standard collection methods
2. Within 2 hours of collection the sample must be spun and
aliquoted
3. Transport?�refrigerated?�?�(2 �?? 8C).

Synonyms/Key Search Words

N/A