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Test Code HCGB hCG, Total, Quantitative

Important Note

This test may be affected by biotin interference. Patients on high dose biotin (5mg/day or more) should not have samples drawn until at least 24 hours after the last biotin administration.

Specimen Type

Plasma

Container/Tube

Li-Heparin, Mint Green Top

Offsite Collection Instructions

1. Collect sample following standard collection methods
2. Within 2 hours of collection the sample must be spun and aliquoted
3. Transport refrigerated  (2 – 8˚C).

Turnaround Time

4 hours

Test Includes

N/A

Preferred Volume

0.5 mL

UCMC Collection Instructions

1. Collect sample following standard collection methods
2. Within 2 hours of collection the sample must be received in Laboratory Service Center
3. Transport room temperature (15 – 25˚C).

STAT Turnaround Time

1  hour

Test Usage

Immunoassay for the in vitro quantitative determination of the sum of human chorionic gonadotropin (hCG) plus the hCG Beta-subunit in human serum and plasma.

 

The Elecsys HCG+Beta test is intended for the early detection of pregnancy.

Critical Results

N/A

Test Limitations

Measurement of the hCG concentration permits the diagnosis of pregnancy just one week after conception. The determination of hCG in the 1st trimester of pregnancy is of particular importance. Elevated values here serve as an indication of chorionic carcinoma, hydatiform mole or multiple pregnancy. Depressed values indicate threatening or missed abortion, ectopic pregnancy, gestosis or intra-uterine death.

 

Elevated hCG concentrations not associated with pregnancy are found in patients with other diseases such as tumors of the germ cells, ovaries, bladder, pancreas, stomach, lungs and liver. The combination of the specific monoclonal antibodies used recognize the holo-hormone, “nicked” forms of hCG, the Beta-core fragment and the free Beta-subunit. The ruthenium-labeled and biotinylated antibodies used are directed against different epitopes of the hCG molecule.

Fee Code

30184702

Stability: Room Temp

2 hours

Stability: Refrigerated

3 days

Stability: Frozen

12 months

Specimen Minimum Volume

0.2 mL

DAY(S) AND TIME(S) PERFORMED

24 hours, 7 days a week including holidays.

STAT DAY(S) AND TIME(S) PERFORMED

Avaliable

CPT

84702

Method Name

Electrochemiluminescence immunoassay (ECLIA)

Reject Due To

Whole blood/unspun samples greater than 6 hours will be rejected.

Synonyms

N/A

Additional Information

N/A

Included in Additional codes

N/A

Coverage Information

N/A

Reference Values

Non pregnant premenopausal females: <5.3 mIU/mL

Non pregnant post menopausal females: <8.3 mIU/mL

Males: <2.6 mIU/mL

 

As with all hCG assays, an isolated negative hCG result does not necessarily rule out pregnancy; for example a woman presenting too early after conception may have undetectable hCG results, which may become detectable if testing is repeated several days later due the hCG doubling time of ~48 hrs. Thus, hCG result should always be interpreted in conjunction with other data; e.g. patient’s medical history, symptoms, results of other tests, clinical impressions, etc.

 

The results from this and of any other diagnostic hCG should be used and interpreted only in the context of the overall clinical picture. If the hCG concentration is inconsistent with, or unsupported by clinical evidence, the laboratory should be contacted to confirm these results by an alternative hCG method.