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Test Code FOLS Serum Folate

Important Note

This test may be affected by biotin interference. Patients on high dose biotin (5mg/day or more) should not have samples drawn until at least 24 hours after the last biotin administration.

Specimen Type

Serum

Container/Tube

Red Top

Offsite Collection Instructions

1. Collect sample following standard collection methods
2. Within 2 hours of collection the sample must be spun and
aliquoted
3. Transport refrigerated (2 – 8˚C)

Turnaround Time

4 hours

Test Includes

N/A

Preferred Volume

0.5 mL

UCMC Collection Instructions

1. Collect sample following standard collection methods
2. Within 2 hours of collection the sample must be received in
Laboratory Service Center
3. Transport room temperature (15 – 25˚C)

STAT Turnaround Time

N/A

Test Usage

Useful in the evaluation of folate deficiency.

Critical Results

N/A

Test Limitations

Hemolysis may significantly increase folate values due to high
concentrations of folate in red blood cells. Therefore, hemolyzed
samples are not suitable for use in this assay.

Folate assays of samples from patients receiving therapy with
certain pharmaceuticals, e.g. methotrexate or leucovorin, are
contraindicated because of the cross-reactivity of folate binding
protein with these compounds.

Samples with extremely high total protein concentrations (e.g.
patients suffering from Waldenström’s macroglobulinemia)
are not suitable for use in this assay. Significant folate
deficiency is characteristically associated with macrocytosis and
megaloblastic anemia. Lower than normal serum folate also has been
reported in patients with neuropsychiatric disorders, in pregnant
women whose fetuses have neural tube defects, and in women who have
recently had spontaneous abortions.

Fee Code

30182746

Synonyms

Folic Acid

Stability: Room Temp

2 hours

Stability: Refrigerated

2 days

Stability: Frozen

4 weeks

Specimen Minimum Volume

0.2 mL

DAY(S) AND TIME(S) PERFORMED

24 hours, 7 days a week including holidays.

STAT DAY(S) AND TIME(S) PERFORMED

N/A

CPT

82746

Method Name

Electrochemiluminescence Immunoassay (ECLIA)

Reference Values

4.0 – 26.0 ng/mL

Reject Due To

Whole blood/unspun samples greater than 6 hours will be
rejected.

Additional Information

N/A

Included in Additional codes

N/A

Coverage Information

N/A