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Test Code ADTS13 ADAMTS-13

Specimen Type



 Light blue top tube, 3.2% sodium citrate.

Preferred Volume

2.7 mL

Offsite Collection Instructions

Whole blood sample must arrive in the laboratory within three hours of specimen collection.


If transport time exceeds three hours, follow centrifugation instructions:

  • Samples must be centrifuged at >1500 x g for 10 minutes at room temperature.
  • Carefully remove the plasma from the cells using a plastic transfer pipette avoiding the buffy coat.
  • Aliquot removed plasma into 2 plastic tubes containing a minimum of 500 uL of specimen in each tube.
  • The plasma samples must then be frozen at -20ºC.
  • Once solidly frozen, they must be shipped on dry ice. Samples that have thawed in transit will be rejected.

Note: For clients who do not have access to dry ice DO NOT freeze the specimen. Follow the centrifugation instructions and send fresh plasma or send whole blood sample. It now becomes vital that the specimen arrives in the lab within three hours of collection.


UCMC Collection Instructions

Samples may be collected and sent to the laboratory at any time.


Test performed Monday-Friday first shift only. Specimen must be in lab by 9 am for that day’s run.

Turnaround Time

1-3 days

STAT Availability

Not Available

Test Usage

Severe deficiency is associated with many acquired and inherited forms of TTP; deficiencies also reported in DIC, connective tissue disorders, malignancies, cirrhosis, and sepsis.

Test Methodology


Additional Information

This test was validated by the University of Chicago Medicine Coagulation Laboratory.  This test has not been cleared or approved by the FDA. The laboratory is regulated under CLIA as qualified to perform high-complexity testing.


All 3.2% sodium citrate light blue top tubes require a ratio of 9 parts blood to 1 part anticoagulant (example: a 3.0 mL tube requires 2.7 mL blood added to 0.3 mL of anticoagulant).

CPT Code

ADAMTS-13 Functional Level: 85397

ADAMTS-13 Inhibitor: 85335

Test Includes

ADAMTS-13 Functional Level and Inhibitor Screen

Reference Range

ADAMTS-13, Functional:  69-133%
ADAMTS-13 Inhibitor Screen: <0.5 Inhibitor Units

Minimum Volume

2.7 mL

Fee Code

ADAMTS-13 Functional Level: 30085397

ADAMTS-13 Inhibitor: 30085335