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Test Code SIR Sirolimus Level

Specimen Type

Blood

Container

Lavender top

Preferred Volume

4 mL

Offsite Collection Instructions

Recommended to draw blood in a lavender-top (EDTA) tube(s) immediately before a scheduled dose.
Specimens submitted for testing on weekdays must be received by the testing lab no later than 3pm to be included in the final run of the day. Samples received after 3pm are held for the next testing day.
Specimens submitted for testing on Saturdays, Sundays and holidays must be received by the testing lab no later than 9am to be included in the single run on those days.  Samples received after 9am are held for the next testing day.

UCMC Collection Instructions

Recommended to draw blood in a lavender-top (EDTA) tube(s) immediately before a scheduled dose.
Specimens submitted for testing on weekdays must be received by the testing lab no later than 3pm to be included in the final run of the day. Samples received after 3pm are held for the next testing day.
Specimens submitted for testing on Saturdays, Sundays and holidays must be received by the testing lab no later than 9am to be included in the single run on those days.  Samples received after 9am are held for the next testing day.

Availability

Monday through Friday 7:00am – 3:00pm, Saturday and Sunday 7:00am-9:00am

Turnaround Time

4 -20 hours

STAT Availability

Not Available

Test Usage

Monitoring whole blood sirolimus concentration during therapy.

Test Methodology

high-performance liquid chromatography/tandem mass spectrometry (LC-MS/MS)

Additional Information

This test was developed and its performance characteristics determined by The University of Chicago Medical Center Clinical Chemistry Laboratories in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code

80195

Test Includes

quantitative determination of sirolimus in whole blood

Critical Results

None

Test Limitations

The recommended therapeutic range applies to trough specimens drawn immediately before a dose. Blood drawn at other times will yield higher results.

Reference Range

3 – 20 ng/mL

Therapeutic (reference) ranges for immunosuppressant drugs have generally not been well established, as these tend to vary depending on the type of transplant, patient clinical status and post-transplant duration/course, concomitant use of other pharmacologic agents of the same class, the dosing/collection intervals and other known factors. This range is based upon commonly published guidelines, and any results are subject to physician interpretation and should be used in conjunction with other diagnostic and clinical information.

Minimum Volume

2 mL

Fee Code

43192

Synonyms

Rapamune