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Test Code HSCRP C-Reactive Protein, High Sensitivity, Plasma

Specimen Type

Preferred: Plasma

Acceptable: Serum


Preferred: Lithium Heparin (Mint Green or Dark Green)

Acceptable: Serum Red Top tube or Gold SST

Preferred Volume

5 mL

Offsite Collection Instructions

1. Serum and plasma tubes should be centrifuged and aliquoted within 2 hours of collection.

2. Aliquoted samples could either be room temperature at 15-25°C or refrigerated at 2-8°C prior and during transportation.

3. If above criteria are not met, specimen will be rejected.

UCMC Collection Instructions

1. Samples need to be received in the lab within 2 hours of collection at room temperature.

2. Greater than 2 hours must be refrigerated at 2-8°C.

3. If the specimen cannot be sent to the lab within 6 hours of collection, it must be spun, aliquoted and refrigerated at 2-8°C.

4. All unspun specimens greater than 6 hours will be rejected.  

5. If above criteria are not met, specimen will be rejected.



Turnaround Time

24 hrs

STAT Availability

Not Available

Test Usage

Measurement of CRP is of use for the detection and evaluation of inflammatory disorders and associated diseases, infection and tissue injury. Highly sensitive measurement of CRP may also be used as an aid in the assessment of the risk of future coronary heart disease. When used as an adjunct to other laboratory evaluation methods of acute coronary syndromes, it may also be an additional independent indicator of recurrent event prog

Test Methodology

Particle-enhanced immunoturbidimetric assay

Additional Information

The American Heart Association and the Centers for Disease Control and Prevention have made several recommendations concerning the use of high sensitivity C-Reactive Protein (hsCRP) in cardiovascular risk assessment.
Testing for any risk assessment should not be performed while there is an indication of infection, systemic inflammation or trauma. Patients with persistently unexplained hsCRP levels above 10 mg/L (95.2 nmol/L) should be evaluated for non-cardiovascular etiologies. When using hsCRP to assess the risk of coronary heart disease, measurements should be made on metabolically stable patients and compared to previous values. Optimally, the average of hsCRP results repeated two weeks apart should be used for risk assessment.
Acute coronary syndrome management should not depend solely on hsCRP measurements. Similarly, application of secondary prevention measures should be based on global risk assessment and not solely on hsCRP measurements. Serial measurements of hsCRP should not be used to monitor treatment.
Pearson TA et al. Markers of Inflammation and Cardiovascular Disease. Application to Clinical and Public Health Practice. A Statement for Healthcare Professionals From the Centers for Disease Control and Prevention and the American Heart  Association. Circulation 2003;107:499–511.

CPT Code


Coverage Information

CMS has established a national coverage policy (NCD) for Medicare for this test as of November 25, 2002. Please document medical necessity.

Reference Range

<5.0 mg/L

Test Limitations

Increases in CRP values are non-specific and should not be interpreted without a complete clinical history.  For diagnostic purposes, the results should always be assessed in conjunction with the patient’s medical history, clinical examination and other findings.

Critical Results


Fee Code


Minimum Volume

2 mL

Test Includes

Quantitative determination of CRP