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Test Code HCGB Beta-Human Chorionic Gonadotropin (HCG), Total, Quantitative, Plasma

Specimen Type

Preferred: Plasma

Acceptable: Serum

Container

Preferred: Lithium Heparin (Mint Green or Dark Green)

Acceptable: Serum Red Top tube or Gold SST

Preferred Volume

5 mL

Offsite Collection Instructions

1. Serum and plasma tubes should be centrifuged and aliquoted within 2 hours of collection.

2. Aliquoted samples could either be room temperature at 15-25°C or refrigerated at 2-8°C prior and during transportation.

3. If above criteria are not met, specimen will be rejected.

UCMC Collection Instructions

1. Samples need to be received in the lab within 2 hours of collection at room temperature.

2. Greater than 2 hours must be refrigerated at 2-8°C.

3. If the specimen cannot be sent to the lab within 6 hours of collection, it must be spun, aliquoted and refrigerated at 2-8°C.

4. All unspun specimens greater than 6 hours will be rejected.  

5. If above criteria are not met, specimen will be rejected.

Availability

24/7

Turnaround Time

4 hours

STAT Availability

Available

Test Usage

Immunoassay for the in vitro quantitative determination of the sum of human chorionic gonadotropin (hCG) plus the hCG Beta-subunit in human serum and plasma. The Elecsys HCG+Beta test is intended for the early detection of pregnancy.

Test Methodology

Roche Elecsys HCG+Beta,  electrochemiluminescence immunoassay (ECLIA)

Additional Information

Measurement of the hCG concentration permits the diagnosis of pregnancy just one week after conception. The determination of hCG in the 1st trimester of pregnancy is of particular importance. Elevated values here serve as an indication of chorionic carcinoma, hydatiform mole or multiple pregnancy. Depressed values indicate threatening or missed abortion, ectopic pregnancy, gestosis or intra-uterine death.
Elevated hCG concentrations not associated with pregnancy are found in patients with other diseases such as tumors of the germ cells, ovaries, bladder, pancreas, stomach, lungs and liver. The combination of the specific monoclonal antibodies used recognize the holo-hormone, “nicked” forms of hCG, the Beta-core fragment and the free Beta-subunit. The ruthenium-labeled and biotinylated antibodies used are directed against different epitopes of the hCG molecule.

CPT Code

84702

STAT Turnaround Time

1 hour

Reference Range

As with all hCG assays, an isolated negative hCG result does not necessarily rule out pregnancy; for example a woman presenting too early after conception may have undetectable hCG results, which may become detectable if testing is repeated several days later due the hCG doubling time of ~48 hrs. Thus, hCG result should always be interpreted in conjunction with other data; e.g. patient’s medical history, symptoms, results of other tests, clinical impressions, etc. The results from this and of any other diagnostic hCG should be used and interpreted only in the context of the overall clinical picture. If the hCG concentration is inconsistent with, or unsupported by clinical evidence, the laboratory should be contacted to confirm these results by an alternative hCG method.

Coverage Information

CMS has established a national coverage policy (NCD) for Medicare for this test as of November 25, 2002. Please document medical necessity. For more details click this link:

 

ncd-details.aspx

Critical Results

None

Fee Code

30184702

Synonyms

HCG, BHCG

Minimum Volume

2 mL

Test Includes

Quantitative determination of the sum of human chorionic gonadotropin (hCG) plus the hCG Beta-subunit in human serum and plasma