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Test Code ACAM Acetaminophen level, Serum

Specimen Type



Red Top tube


*Note: Tubes containing serum separating gel will be rejected.


Preferred Volume

5 mL

Offsite Collection Instructions

1. Serum tubes should be centrifuged and aliquoted within 2 hours of collection.

2. Aliquoted samples could either be room temperature at 15-25°C or refrigerated at 2-8°C prior and during transportation.

3. If above criteria are not met, specimen will be rejected.

UCMC Collection Instructions

1. First request should be 4 hours post-dose, subsequently every 4 hours twice per admission for a total of 12 hours.

2. Samples need to be received in the lab within 2 hours of collection at room temperature.

3. Greater than 2 hours must be refrigerated at 2-8°C.

4. If the specimen cannot be sent to the lab within 6 hours of collection, it must be spun, aliquoted and refrigerated at 2-8°C.

5. All unspun specimens greater than 6 hours will be rejected.   

6. If above criteria are not met, specimen will be rejected.



Turnaround Time

4 hours

STAT Availability


Test Methodology

Enzyme-Multiplied Immunoassay Technique (EMIT)

Additional Information

Early diagnosis of acetaminophen induced hepatotoxicity is important since initiation of therapy within 16 hours of ingestion lessens the potential for hepatic injury and decreases the mortality rate.

CPT Code


Critical Results

Critical Value: >150 µg/mL

Reference Range

Therapeutic range:  10 – 30 µg/mL  

Minimum Volume

2 mL

STAT Turnaround Time

1 hour

Fee Code


Test Includes

Quantitative determination of Acetaminophen